diff --git a/vm_core.h b/vm_core.h
index 2c38911d58..95cd2d87d9 100644
--- a/vm_core.h
+++ b/vm_core.h
@@ -698,6 +698,18 @@ typedef struct rb_vm_struct {
 #define RUBY_VM_FIBER_MACHINE_STACK_SIZE_MIN  (  16 * 1024 * sizeof(VALUE)) /*   64 KB or  128 KB */
 #endif
 
+#if __has_feature(memory_sanitizer) || __has_feature(address_sanitizer)
+/* It seems sanitizers consume A LOT of machine stacks */
+#undef  RUBY_VM_THREAD_MACHINE_STACK_SIZE
+#define RUBY_VM_THREAD_MACHINE_STACK_SIZE     (1024 * 1024 * sizeof(VALUE))
+#undef  RUBY_VM_THREAD_MACHINE_STACK_SIZE_MIN
+#define RUBY_VM_THREAD_MACHINE_STACK_SIZE_MIN ( 512 * 1024 * sizeof(VALUE))
+#undef  RUBY_VM_FIBER_MACHINE_STACK_SIZE
+#define RUBY_VM_FIBER_MACHINE_STACK_SIZE      ( 256 * 1024 * sizeof(VALUE))
+#undef  RUBY_VM_FIBER_MACHINE_STACK_SIZE_MIN
+#define RUBY_VM_FIBER_MACHINE_STACK_SIZE_MIN  ( 128 * 1024 * sizeof(VALUE))
+#endif
+
 /* optimize insn */
 #define INTEGER_REDEFINED_OP_FLAG (1 << 0)
 #define FLOAT_REDEFINED_OP_FLAG  (1 << 1)