diff --git a/test/-ext-/debug/test_debug.rb b/test/-ext-/debug/test_debug.rb
index 8a351d74fa..a6e0af2314 100644
--- a/test/-ext-/debug/test_debug.rb
+++ b/test/-ext-/debug/test_debug.rb
@@ -72,4 +72,19 @@ class TestDebug < Test::Unit::TestCase
     end
     assert_equal true, x, '[Bug #15105]'
   end
+
+  # This is a YJIT test, but we can't test this without a C extension that calls
+  # rb_debug_inspector_open(), so we're testing it using "-test-/debug" here.
+  def test_yjit_invalidates_setlocal_after_inspector_call
+    val = setlocal_after_proc_call(proc { Bug::Debug.inspector; :ok })
+    assert_equal :ok, val
+  end if defined?(RubyVM::YJIT) && RubyVM::YJIT.enabled?
+
+  private
+
+  def setlocal_after_proc_call(block)
+    local = block.call # setlocal followed by OPTIMIZED_METHOD_TYPE_CALL
+    itself # split a block using a C call
+    local # getlocal
+  end
 end
diff --git a/version.h b/version.h
index 3b8d50b4bf..d5294f759c 100644
--- a/version.h
+++ b/version.h
@@ -11,7 +11,7 @@
 # define RUBY_VERSION_MINOR RUBY_API_VERSION_MINOR
 #define RUBY_VERSION_TEENY 8
 #define RUBY_RELEASE_DATE RUBY_RELEASE_YEAR_STR"-"RUBY_RELEASE_MONTH_STR"-"RUBY_RELEASE_DAY_STR
-#define RUBY_PATCHLEVEL 155
+#define RUBY_PATCHLEVEL 156
 
 #include "ruby/version.h"
 #include "ruby/internal/abi.h"
diff --git a/yjit/src/codegen.rs b/yjit/src/codegen.rs
index d702b1133e..168d870078 100644
--- a/yjit/src/codegen.rs
+++ b/yjit/src/codegen.rs
@@ -7449,7 +7449,6 @@ fn gen_send_general(
 
                     }
                     OPTIMIZED_METHOD_TYPE_CALL => {
-
                         if block.is_some() {
                             gen_counter_incr(asm, Counter::send_call_block);
                             return None;
@@ -7501,8 +7500,9 @@ fn gen_send_general(
 
                         let stack_ret = asm.stack_push(Type::Unknown);
                         asm.mov(stack_ret, ret);
-                        return Some(KeepCompiling);
 
+                        // End the block to allow invalidating the next instruction
+                        return jump_to_next_insn(jit, asm);
                     }
                     OPTIMIZED_METHOD_TYPE_BLOCK_CALL => {
                         gen_counter_incr(asm, Counter::send_optimized_method_block_call);