diff --git a/gc/default.c b/gc/default.c
index d60fba3ff0..addaf01fc2 100644
--- a/gc/default.c
+++ b/gc/default.c
@@ -788,7 +788,9 @@ heap_page_in_global_empty_pages_pool(rb_objspace_t *objspace, struct heap_page *
         GC_ASSERT(page->slot_size == 0);
         GC_ASSERT(page->size_pool == NULL);
         GC_ASSERT(page->free_slots == 0);
-        GC_ASSERT(page->freelist == NULL);
+        asan_unpoisoning_memory_region(&page->freelist, sizeof(&page->freelist)) {
+            GC_ASSERT(page->freelist == NULL);
+        }
 
         return true;
     }
@@ -1177,12 +1179,6 @@ tick(void)
 #define MEASURE_LINE(expr) expr
 #endif /* USE_TICK_T */
 
-#define asan_unpoisoning_object(obj) \
-    for (void *poisoned = asan_unpoison_object_temporary(obj), \
-              *unpoisoning = &poisoned; /* flag to loop just once */ \
-         unpoisoning; \
-         unpoisoning = asan_poison_object_restore(obj, poisoned))
-
 #define FL_CHECK2(name, x, pred) \
     ((RGENGC_CHECK_MODE && SPECIAL_CONST_P(x)) ? \
      (rb_bug(name": SPECIAL_CONST (%p)", (void *)(x)), 0) : (pred))
diff --git a/internal/sanitizers.h b/internal/sanitizers.h
index b0eb1fc851..94f4e4165a 100644
--- a/internal/sanitizers.h
+++ b/internal/sanitizers.h
@@ -206,6 +206,35 @@ asan_poison_object_restore(VALUE obj, void *ptr)
     return NULL;
 }
 
+#define asan_unpoisoning_object(obj) \
+    for (void *poisoned = asan_unpoison_object_temporary(obj), \
+              *unpoisoning = &poisoned; /* flag to loop just once */ \
+         unpoisoning; \
+         unpoisoning = asan_poison_object_restore(obj, poisoned))
+
+
+static inline void *
+asan_unpoison_memory_region_temporary(void *ptr, size_t len)
+{
+    void *poisoned_ptr = __asan_region_is_poisoned(ptr, len);
+    asan_unpoison_memory_region(ptr, len, false);
+    return poisoned_ptr;
+}
+
+static inline void *
+asan_poison_memory_region_restore(void *ptr, size_t len, void *poisoned_ptr)
+{
+    if (poisoned_ptr) {
+        asan_poison_memory_region(ptr, len);
+    }
+    return NULL;
+}
+
+#define asan_unpoisoning_memory_region(ptr, len) \
+    for (void *poisoned = asan_unpoison_memory_region_temporary(ptr, len), \
+              *unpoisoning = &poisoned; /* flag to loop just once */ \
+         unpoisoning; \
+         unpoisoning = asan_poison_memory_region_restore(ptr, len, poisoned))
 
 /**
  * Checks if the given pointer is on an ASAN fake stack. If so, it returns the