diff --git a/cmake/QtExecutableHelpers.cmake b/cmake/QtExecutableHelpers.cmake
index 4c96c811e96..608d52437ea 100644
--- a/cmake/QtExecutableHelpers.cmake
+++ b/cmake/QtExecutableHelpers.cmake
@@ -71,7 +71,12 @@ function(qt_internal_add_executable name)
         endif()
     endif()
 
-    if(arg_QT_APP AND QT_FEATURE_debug_and_release AND CMAKE_VERSION VERSION_GREATER_EQUAL "3.19.0")
+    get_cmake_property(is_multi_config GENERATOR_IS_MULTI_CONFIG)
+    if(arg_QT_APP
+            AND QT_FEATURE_debug_and_release
+            AND CMAKE_VERSION VERSION_GREATER_EQUAL "3.19.0"
+            AND is_multi_config
+        )
         set_property(TARGET "${name}"
             PROPERTY EXCLUDE_FROM_ALL "$<NOT:$<CONFIG:${QT_MULTI_CONFIG_FIRST_CONFIG}>>")
     endif()
diff --git a/cmake/QtToolHelpers.cmake b/cmake/QtToolHelpers.cmake
index 641b44f73a3..0b85ec58af1 100644
--- a/cmake/QtToolHelpers.cmake
+++ b/cmake/QtToolHelpers.cmake
@@ -168,7 +168,10 @@ function(qt_internal_add_tool target_name)
                  APPEND PROPERTY
                  EXPORT_PROPERTIES "_qt_package_version")
 
-    if(CMAKE_VERSION VERSION_GREATER_EQUAL "3.19.0" AND QT_FEATURE_debug_and_release)
+    get_cmake_property(is_multi_config GENERATOR_IS_MULTI_CONFIG)
+    if(CMAKE_VERSION VERSION_GREATER_EQUAL "3.19.0"
+            AND QT_FEATURE_debug_and_release
+            AND is_multi_config)
         set_property(TARGET "${target_name}"
             PROPERTY EXCLUDE_FROM_ALL "$<NOT:$<CONFIG:${QT_MULTI_CONFIG_FIRST_CONFIG}>>")
     endif()