diff --git a/cmake/QtWasmHelpers.cmake b/cmake/QtWasmHelpers.cmake
index 6c42bd124d5..b30f5895c7a 100644
--- a/cmake/QtWasmHelpers.cmake
+++ b/cmake/QtWasmHelpers.cmake
@@ -72,6 +72,12 @@ function (qt_internal_setup_wasm_target_properties wasmTarget)
 
         target_link_options("${wasmTarget}" INTERFACE "SHELL:-s ASYNCIFY" "-Os")
         target_compile_definitions("${wasmTarget}" INTERFACE QT_HAVE_EMSCRIPTEN_ASYNCIFY)
+    elseif ("QT_EMSCRIPTEN_ASYNCIFY=2" IN_LIST QT_QMAKE_DEVICE_OPTIONS)
+        # Enable JSPI (also known as asyncify 2). Unlike asyncify 1 this
+        # is supported natively by the browsers, and does not require
+        # enabling optimizations.
+        target_link_options("${wasmTarget}" INTERFACE "SHELL:-s JSPI")
+        target_compile_definitions("${wasmTarget}" INTERFACE QT_HAVE_EMSCRIPTEN_ASYNCIFY)
     endif()
 
     #  Set ASYNCIFY_IMPORTS unconditionally in order to support enabling asyncify at link time.
diff --git a/mkspecs/common/wasm/wasm.conf b/mkspecs/common/wasm/wasm.conf
index 51fa9d7ceb3..6b967d79f24 100644
--- a/mkspecs/common/wasm/wasm.conf
+++ b/mkspecs/common/wasm/wasm.conf
@@ -8,10 +8,10 @@ include(../clang.conf)
 load(device_config)
 load(emcc_ver)
 
-# Support enabling asyncify by configuring with "-device-option QT_EMSCRIPTEN_ASYNCIFY=1"
+# Support enabling asyncify by configuring with "-device-option QT_EMSCRIPTEN_ASYNCIFY"
 !isEmpty(QT_EMSCRIPTEN_ASYNCIFY): {
-    !equals(QT_EMSCRIPTEN_ASYNCIFY, 1):!equals(QT_EMSCRIPTEN_ASYNCIFY, 0): \
-        message(Error: The value for QT_EMSCRIPTEN_ASYNCIFY must be 0 or 1)
+    !equals(QT_EMSCRIPTEN_ASYNCIFY, 2):!equals(QT_EMSCRIPTEN_ASYNCIFY, 1):!equals(QT_EMSCRIPTEN_ASYNCIFY, 0): \
+        message(Error: The value for QT_EMSCRIPTEN_ASYNCIFY must be 0, 1, or 2)
     equals(QT_EMSCRIPTEN_ASYNCIFY, 1): {
         QMAKE_CFLAGS += -DQT_HAVE_EMSCRIPTEN_ASYNCIFY
         QMAKE_CXXFLAGS += -DQT_HAVE_EMSCRIPTEN_ASYNCIFY
@@ -23,6 +23,11 @@ load(emcc_ver)
         # are omitted. Enable optimizations also for debug builds.
         QMAKE_LFLAGS_DEBUG  += -Os
     }
+    equals(QT_EMSCRIPTEN_ASYNCIFY, 2): {
+        QMAKE_CFLAGS += -DQT_HAVE_EMSCRIPTEN_ASYNCIFY
+        QMAKE_CXXFLAGS += -DQT_HAVE_EMSCRIPTEN_ASYNCIFY
+        QMAKE_LFLAGS += -s JSPI
+    }
 }
 
 # Declare async functions