diff --git a/configure.cmake b/configure.cmake
index 95995a558df..adc3d481b01 100644
--- a/configure.cmake
+++ b/configure.cmake
@@ -1274,6 +1274,16 @@ if (TEST_architecture_arch STREQUAL x86_64 OR TEST_architecture_arch STREQUAL i3
             MESSAGE [=[
 All x86 intrinsics and SIMD support were disabled. If this was in error, check
 the result of the build in config.tests/x86intrin and report at https://bugreports.qt.io.
+]=]
+        )
+    elseif (MSVC AND CLANG)
+        # Warn only
+        qt_configure_add_report_entry(
+            TYPE WARNING
+            CONDITION (NOT QT_FEATURE_x86intrin)
+            MESSAGE [=[
+x86 intrinsics support is disabled for clang-cl build. This might be necessary due to
+https://github.com/llvm/llvm-project/issues/53520
 ]=]
         )
     else()
diff --git a/src/corelib/global/qnumeric_p.h b/src/corelib/global/qnumeric_p.h
index 9765ce4a319..40c459991c8 100644
--- a/src/corelib/global/qnumeric_p.h
+++ b/src/corelib/global/qnumeric_p.h
@@ -180,7 +180,7 @@ static inline bool convertDoubleTo(double v, T *value, bool allow_precision_upgr
     // correct, but Clang, ICC and MSVC don't realize that it's a constant and
     // the math call stays in the compiled code.
 
-#ifdef Q_PROCESSOR_X86_64
+#if defined(Q_PROCESSOR_X86_64) && defined(__SSE2__)
     // Of course, UB doesn't apply if we use intrinsics, in which case we are
     // allowed to dpeend on exactly the processor's behavior. This
     // implementation uses the truncating conversions from Scalar Double to
diff --git a/src/corelib/global/qsimd.h b/src/corelib/global/qsimd.h
index 6ed7821e269..4ef925ca337 100644
--- a/src/corelib/global/qsimd.h
+++ b/src/corelib/global/qsimd.h
@@ -55,7 +55,7 @@
 
 #if defined(Q_PROCESSOR_X86) && defined(Q_CC_MSVC)
 // MSVC doesn't define __SSE2__, so do it ourselves
-#  if (defined(_M_X64) || _M_IX86_FP >= 2)
+#  if (defined(_M_X64) || _M_IX86_FP >= 2) && defined(QT_COMPILER_SUPPORTS_SSE2)
 #    define __SSE__ 1
 #    define __SSE2__ 1
 #  endif