diff --git a/cmake/QtBuildHelpers.cmake b/cmake/QtBuildHelpers.cmake
index 662b6be581c..941b6d74ef1 100644
--- a/cmake/QtBuildHelpers.cmake
+++ b/cmake/QtBuildHelpers.cmake
@@ -444,6 +444,7 @@ macro(qt_internal_setup_build_and_global_variables)
     qt_internal_setup_build_examples()
 
     qt_internal_set_qt_host_path()
+    qt_internal_setup_find_host_info_package()
 
     qt_internal_setup_build_docs()
 
@@ -465,7 +466,6 @@ macro(qt_internal_setup_build_and_global_variables)
     qt_internal_check_msvc_versions()
     qt_internal_check_host_path_set_for_cross_compiling()
     qt_internal_setup_android_platform_specifics()
-    qt_internal_setup_find_host_info_package()
     qt_internal_setup_tool_path_command()
     qt_internal_setup_default_target_function_options()
     qt_internal_set_default_rpath_settings()
diff --git a/cmake/QtBuildPathsHelpers.cmake b/cmake/QtBuildPathsHelpers.cmake
index be2e26bc4a0..b011b905fe9 100644
--- a/cmake/QtBuildPathsHelpers.cmake
+++ b/cmake/QtBuildPathsHelpers.cmake
@@ -263,3 +263,20 @@ macro(qt_internal_setup_paths_and_prefixes)
 
     qt_internal_set_qt_apple_support_files_path()
 endmacro()
+
+# Returns the prefix for the variables defined by HostInfo package. The prefix
+# is based on version information provided by HostInfo. Falls back to current
+# project version if ${INSTALL_CMAKE_NAMESPACE}HostInfo_VERSION_MAJOR is not
+# defined.
+function(qt_internal_get_host_info_var_prefix out_var)
+    if(${INSTALL_CMAKE_NAMESPACE}HostInfo_VERSION_MAJOR)
+        set(${out_var} "QT${${INSTALL_CMAKE_NAMESPACE}HostInfo_VERSION_MAJOR}_HOST_INFO"
+            PARENT_SCOPE)
+    else()
+        # This is not a valid way to define the host info versioned prefix, but
+        # it's backward compatible with Qt versions older than 6.10.
+        #
+        # TODO: remove once Qt LTS versions older than 6.10 reach end of life.
+        set(${out_var} "QT${PROJECT_VERSION_MAJOR}_HOST_INFO" PARENT_SCOPE)
+    endif()
+endfunction()
diff --git a/cmake/QtDocsHelpers.cmake b/cmake/QtDocsHelpers.cmake
index 2df526ad8bb..6699ecc0620 100644
--- a/cmake/QtDocsHelpers.cmake
+++ b/cmake/QtDocsHelpers.cmake
@@ -131,8 +131,9 @@ function(qt_internal_add_docs)
     set(tool_dependencies_enabled TRUE)
     if(NOT "${QT_HOST_PATH}" STREQUAL "")
         set(tool_dependencies_enabled FALSE)
-        set(doc_tools_bin "${QT_HOST_PATH}/${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BINDIR}")
-        set(doc_tools_libexec "${QT_HOST_PATH}/${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}")
+        qt_internal_get_host_info_var_prefix(host_info_var_prefix)
+        set(doc_tools_bin "${QT_HOST_PATH}/${${host_info_var_prefix}_BINDIR}")
+        set(doc_tools_libexec "${QT_HOST_PATH}/${${host_info_var_prefix}_LIBEXECDIR}")
     elseif(NOT "${QT_OPTIONAL_TOOLS_PATH}" STREQUAL "")
         set(tool_dependencies_enabled FALSE)
         set(doc_tools_bin "${QT_OPTIONAL_TOOLS_PATH}/${INSTALL_BINDIR}")
diff --git a/cmake/QtMkspecHelpers.cmake b/cmake/QtMkspecHelpers.cmake
index a9612966b5f..a7f239f1b6d 100644
--- a/cmake/QtMkspecHelpers.cmake
+++ b/cmake/QtMkspecHelpers.cmake
@@ -114,7 +114,8 @@ macro(qt_internal_setup_platform_definitions_and_mkspec)
     endif()
 
     if(CMAKE_CROSSCOMPILING)
-        set(QT_QMAKE_HOST_MKSPEC "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_QMAKE_MKSPEC}")
+        qt_internal_get_host_info_var_prefix(host_info_var_prefix)
+        set(QT_QMAKE_HOST_MKSPEC "${${host_info_var_prefix}_QMAKE_MKSPEC}")
     else()
         set(QT_QMAKE_HOST_MKSPEC "${QT_QMAKE_TARGET_MKSPEC}")
     endif()
diff --git a/cmake/QtPlatformAndroid.cmake b/cmake/QtPlatformAndroid.cmake
index 1ded0197205..62f0b93c75c 100644
--- a/cmake/QtPlatformAndroid.cmake
+++ b/cmake/QtPlatformAndroid.cmake
@@ -136,8 +136,10 @@ define_property(TARGET
 
 # Returns test execution arguments for Android targets
 function(qt_internal_android_test_runner_arguments target out_test_runner out_test_arguments)
-    set(${out_test_runner} "${QT_HOST_PATH}/${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BINDIR}/androidtestrunner" PARENT_SCOPE)
-    set(deployment_tool "${QT_HOST_PATH}/${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BINDIR}/androiddeployqt")
+    qt_internal_get_host_info_var_prefix(host_info_var_prefix)
+    set(host_bin_dir "${QT_HOST_PATH}/${${host_info_var_prefix}_BINDIR}")
+    set(${out_test_runner} "${host_bin_dir}/androidtestrunner" PARENT_SCOPE)
+    set(deployment_tool "${host_bin_dir}/androiddeployqt")
 
     qt_internal_android_get_target_android_build_dir(${target} android_build_dir)
     set(${out_test_arguments}
diff --git a/cmake/QtPriHelpers.cmake b/cmake/QtPriHelpers.cmake
index 7b023af6e3c..b450681d61c 100644
--- a/cmake/QtPriHelpers.cmake
+++ b/cmake/QtPriHelpers.cmake
@@ -738,9 +738,10 @@ function(qt_generate_global_config_pri_file)
     endif()
 
     if(CMAKE_CROSSCOMPILING)
+        qt_internal_get_host_info_var_prefix(host_info_var_prefix)
         string(APPEND content "host_build {
-    QT_ARCH = ${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_ARCH}
-    QT_BUILDABI = ${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BUILDABI}
+    QT_ARCH = ${${host_info_var_prefix}_ARCH}
+    QT_BUILDABI = ${${host_info_var_prefix}_BUILDABI}
     QT_TARGET_ARCH = ${TEST_architecture_arch}
     QT_TARGET_BUILDABI = ${TEST_buildAbi}
 } else {
@@ -965,8 +966,9 @@ function(qt_generate_global_module_pri_file)
     set(arch "${TEST_architecture_arch}")
     list(JOIN TEST_subarch_result " " subarchs)
     if(CMAKE_CROSSCOMPILING)
-        set(host_arch "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_ARCH}")
-        list(JOIN QT${PROJECT_VERSION_MAJOR}_HOST_INFO_SUBARCHS " " host_subarchs)
+        qt_internal_get_host_info_var_prefix(host_info_var_prefix)
+        set(host_arch "${${host_info_var_prefix}_ARCH}")
+        list(JOIN ${host_info_var_prefix}_SUBARCHS " " host_subarchs)
         string(APPEND content "host_build {
     QT_CPU_FEATURES.${host_arch} = ${host_subarchs}
 } else {
diff --git a/cmake/QtQmakeHelpers.cmake b/cmake/QtQmakeHelpers.cmake
index c618fa05109..c1dbb0d542d 100644
--- a/cmake/QtQmakeHelpers.cmake
+++ b/cmake/QtQmakeHelpers.cmake
@@ -125,6 +125,7 @@ Prefix=${prefix}
         endif()
     endif()
 
+    qt_internal_get_host_info_var_prefix(host_info_var_prefix)
     string(APPEND content
         "[Paths]
 Prefix=${ext_prefix_relative_to_conf_file}
@@ -142,9 +143,9 @@ Examples=${INSTALL_EXAMPLESDIR}
 Tests=${INSTALL_TESTSDIR}
 Settings=${INSTALL_SYSCONFDIR}
 HostPrefix=${host_prefix_relative_to_conf_file}
-HostBinaries=${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BINDIR}
-HostLibraries=${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBDIR}
-HostLibraryExecutables=${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}
+HostBinaries=${${host_info_var_prefix}_BINDIR}
+HostLibraries=${${host_info_var_prefix}_LIBDIR}
+HostLibraryExecutables=${${host_info_var_prefix}_LIBEXECDIR}
 HostData=${ext_datadir_relative_to_host_prefix}
 Sysroot=${sysroot}
 SysrootifyPrefix=${sysrootify_prefix}
@@ -169,7 +170,7 @@ HostSpec=${QT_QMAKE_HOST_MKSPEC}
         set(wrapper_prefix "host-")
     endif()
 
-    set(host_qt_bindir "${host_prefix}/${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_BINDIR}")
+    set(host_qt_bindir "${host_prefix}/${${host_info_var_prefix}_BINDIR}")
     file(TO_NATIVE_PATH "${host_qt_bindir}" host_qt_bindir)
 
     if(QT_CREATE_VERSIONED_HARD_LINK AND QT_WILL_INSTALL)
diff --git a/cmake/QtTargetHelpers.cmake b/cmake/QtTargetHelpers.cmake
index 658239628d2..43c27f9f910 100644
--- a/cmake/QtTargetHelpers.cmake
+++ b/cmake/QtTargetHelpers.cmake
@@ -1239,9 +1239,10 @@ function(qt_internal_create_tracepoints name tracepoints_file)
         endif()
 
         if(NOT "${QT_HOST_PATH}" STREQUAL "")
+            qt_internal_get_host_info_var_prefix(host_info_var_prefix)
             qt_path_join(tracegen
                 "${QT_HOST_PATH}"
-                "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}"
+                "${${host_info_var_prefix}_LIBEXECDIR}"
                 "tracegen")
         else()
             set(tracegen "${QT_CMAKE_EXPORT_NAMESPACE}::tracegen")
@@ -1276,9 +1277,10 @@ function(qt_internal_generate_tracepoints name provider)
         endforeach()
 
         if(NOT "${QT_HOST_PATH}" STREQUAL "")
+            qt_internal_get_host_info_var_prefix(host_info_var_prefix)
             qt_path_join(tracepointgen
                 "${QT_HOST_PATH}"
-                "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}"
+                "${${host_info_var_prefix}_LIBEXECDIR}"
                 "tracepointgen")
         else()
             set(tracepointgen "${QT_CMAKE_EXPORT_NAMESPACE}::tracepointgen")
@@ -1309,9 +1311,10 @@ function(qt_internal_generate_tracepoints name provider)
         endif()
 
         if(NOT "${QT_HOST_PATH}" STREQUAL "")
+            qt_internal_get_host_info_var_prefix(host_info_var_prefix)
             qt_path_join(tracegen
                 "${QT_HOST_PATH}"
-                "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}"
+                "${${host_info_var_prefix}_LIBEXECDIR}"
                 "tracegen")
         else()
             set(tracegen "${QT_CMAKE_EXPORT_NAMESPACE}::tracegen")
diff --git a/src/gui/CMakeLists.txt b/src/gui/CMakeLists.txt
index cd4f6c8d2df..25e3f210d17 100644
--- a/src/gui/CMakeLists.txt
+++ b/src/gui/CMakeLists.txt
@@ -961,9 +961,10 @@ if (QT_FEATURE_vulkan)
         if(CMAKE_HOST_WIN32)
             set(host_executable_suffix ".exe")
         endif()
+        qt_internal_get_host_info_var_prefix(host_info_var_prefix)
         qt_path_join(qvkgen
             "${QT_HOST_PATH}"
-            "${QT${PROJECT_VERSION_MAJOR}_HOST_INFO_LIBEXECDIR}"
+            "${${host_info_var_prefix}_LIBEXECDIR}"
             "qvkgen${host_executable_suffix}")
     elseif(QT_OPTIONAL_TOOLS_PATH)
         qt_path_join(qvkgen