diff --git a/cmake/QtBuild.cmake b/cmake/QtBuild.cmake
index 56c7ca3db55..c4bf173e8b3 100644
--- a/cmake/QtBuild.cmake
+++ b/cmake/QtBuild.cmake
@@ -284,21 +284,21 @@ if(WIN32)
     if(CMAKE_SIZEOF_VOID_P EQUAL 8)
         list(APPEND QT_DEFAULT_PLATFORM_DEFINITIONS WIN64 _WIN64)
     endif()
-    if(MSVC)
-        if (CLANG)
+
+    if(CLANG)
+        if(CMAKE_CXX_COMPILER_FRONTEND_VARIANT STREQUAL "MSVC" OR MSVC)
             set(QT_DEFAULT_MKSPEC win32-clang-msvc)
-        elseif(CMAKE_SYSTEM_PROCESSOR STREQUAL "arm64")
+        elseif(CMAKE_CXX_COMPILER_FRONTEND_VARIANT STREQUAL "GNU" OR MINGW)
+            set(QT_DEFAULT_MKSPEC win32-clang-g++)
+        endif()
+    elseif(MSVC)
+        if(CMAKE_SYSTEM_PROCESSOR STREQUAL "arm64")
             set(QT_DEFAULT_MKSPEC win32-arm64-msvc)
         else()
             set(QT_DEFAULT_MKSPEC win32-msvc)
         endif()
-    elseif(CLANG AND MINGW)
-        set(QT_DEFAULT_MKSPEC win32-clang-g++)
     elseif(MINGW)
         set(QT_DEFAULT_MKSPEC win32-g++)
-    endif()
-
-    if (MINGW)
         list(APPEND QT_DEFAULT_PLATFORM_DEFINITIONS MINGW_HAS_SECURE_API=1)
     endif()
 elseif(LINUX)