diff --git a/cmake/QtInternalTargets.cmake b/cmake/QtInternalTargets.cmake
index b95257cc69e..89d0f893e9b 100644
--- a/cmake/QtInternalTargets.cmake
+++ b/cmake/QtInternalTargets.cmake
@@ -262,6 +262,13 @@ endif()
 # Taken from mkspecs/common/msvc-version.conf and mkspecs/common/msvc-desktop.conf
 if (MSVC AND NOT CLANG)
     if (MSVC_VERSION GREATER_EQUAL 1799)
+        set_target_properties(PlatformCommonInternal PROPERTIES _qt_cpp_compiler_frontend_variant
+            "${CMAKE_CXX_COMPILER_FRONTEND_VARIANT}")
+
+        # Protect against adding these flags when building qtbase with MSVC, and qtwebengine using
+        # clang-cl.
+        set(is_not_clang_cl_start "$<$<NOT:$<STREQUAL:$<CXX_COMPILER_ID>,Clang>>:")
+        set(is_not_clang_cl_end ">")
         target_compile_options(PlatformCommonInternal INTERFACE
             -FS
             -Zc:rvalueCast
@@ -271,18 +278,18 @@ if (MSVC AND NOT CLANG)
     if (MSVC_VERSION GREATER_EQUAL 1899)
         target_compile_options(PlatformCommonInternal INTERFACE
             -Zc:strictStrings
-            -Zc:throwingNew
+            "${is_not_clang_cl_start}-Zc:throwingNew${is_not_clang_cl_end}"
         )
     endif()
     if (MSVC_VERSION GREATER_EQUAL 1909) # MSVC 2017
         target_compile_options(PlatformCommonInternal INTERFACE
-            -Zc:referenceBinding
+            "${is_not_clang_cl_start}-Zc:referenceBinding${is_not_clang_cl_end}"
             -Zc:ternary
         )
     endif()
     if (MSVC_VERSION GREATER_EQUAL 1919) # MSVC 2019
         target_compile_options(PlatformCommonInternal INTERFACE
-            -Zc:externConstexpr
+            "${is_not_clang_cl_start}-Zc:externConstexpr${is_not_clang_cl_end}"
             #-Zc:lambda # Buggy. TODO: Enable again when stable enough.
             #-Zc:preprocessor # breaks build due to bug in default Windows SDK 10.0.19041
         )