diff --git a/configure.cmake b/configure.cmake
index 32b4abb228b..f8cb1dccadf 100644
--- a/configure.cmake
+++ b/configure.cmake
@@ -939,7 +939,6 @@ qt_feature("printsupport" PRIVATE
 )
 qt_feature("sql" PRIVATE
     LABEL "Qt Sql"
-    CONDITION QT_FEATURE_thread AND NOT WASM
 )
 qt_feature("testlib" PRIVATE
     LABEL "Qt Testlib"
diff --git a/src/plugins/sqldrivers/sqlite/CMakeLists.txt b/src/plugins/sqldrivers/sqlite/CMakeLists.txt
index 1fba18290bc..aea1c14a426 100644
--- a/src/plugins/sqldrivers/sqlite/CMakeLists.txt
+++ b/src/plugins/sqldrivers/sqlite/CMakeLists.txt
@@ -95,3 +95,8 @@ qt_internal_extend_target(QSQLiteDriverPlugin CONDITION NOT QT_FEATURE_dlopen AN
     DEFINES
         SQLITE_OMIT_LOAD_EXTENSION
 )
+
+qt_internal_extend_target(QSQLiteDriverPlugin CONDITION NOT QT_FEATURE_thread AND NOT QT_FEATURE_system_sqlite
+    DEFINES
+        SQLITE_THREADSAFE=0
+)