diff --git a/include/my_valgrind.h b/include/my_valgrind.h
index 260521d4d4b..a24ad597d36 100644
--- a/include/my_valgrind.h
+++ b/include/my_valgrind.h
@@ -1,4 +1,4 @@
-/* Copyright (C) 2010, 2020, MariaDB Corporation.
+/* Copyright (C) 2010, 2022, MariaDB Corporation.
 
    This program is free software; you can redistribute it and/or modify
    it under the terms of the GNU General Public License as published by
@@ -37,6 +37,11 @@
 # define MEM_GET_VBITS(a,b,len) __msan_copy_shadow(b,a,len)
 # define MEM_SET_VBITS(a,b,len) __msan_copy_shadow(a,b,len)
 # define REDZONE_SIZE 8
+# ifdef __linux__
+#  define MSAN_STAT_WORKAROUND(st) MEM_MAKE_DEFINED(st, sizeof(*st))
+# else
+#  define MSAN_STAT_WORKAROUND(st) ((void) 0)
+# endif
 #elif defined(HAVE_VALGRIND_MEMCHECK_H) && defined(HAVE_valgrind)
 # include <valgrind/memcheck.h>
 # define HAVE_MEM_CHECK
@@ -49,6 +54,7 @@
 # define MEM_GET_VBITS(a,b,len) VALGRIND_GET_VBITS(a,b,len)
 # define MEM_SET_VBITS(a,b,len) VALGRIND_SET_VBITS(a,b,len)
 # define REDZONE_SIZE 8
+# define MSAN_STAT_WORKAROUND(st) ((void) 0)
 #elif defined(__SANITIZE_ADDRESS__) && (!defined(_MSC_VER) || defined (__clang__))
 # include <sanitizer/asan_interface.h>
 /* How to do manual poisoning:
@@ -62,6 +68,7 @@ https://github.com/google/sanitizers/wiki/AddressSanitizerManualPoisoning */
 # define MEM_CHECK_DEFINED(a,len) ((void) 0)
 # define MEM_GET_VBITS(a,b,len) ((void) 0)
 # define MEM_SET_VBITS(a,b,len) ((void) 0)
+# define MSAN_STAT_WORKAROUND(st) ((void) 0)
 # define REDZONE_SIZE 8
 #else
 # define MEM_UNDEFINED(a,len) ((void) 0)
@@ -73,6 +80,7 @@ https://github.com/google/sanitizers/wiki/AddressSanitizerManualPoisoning */
 # define MEM_GET_VBITS(a,b,len) ((void) 0)
 # define MEM_SET_VBITS(a,b,len) ((void) 0)
 # define REDZONE_SIZE 0
+# define MSAN_STAT_WORKAROUND(st) ((void) 0)
 #endif /* __has_feature(memory_sanitizer) */
 
 #ifdef HAVE_valgrind
diff --git a/mysys/my_lib.c b/mysys/my_lib.c
index ca50699b4c3..fedd1c7ab4d 100644
--- a/mysys/my_lib.c
+++ b/mysys/my_lib.c
@@ -1,5 +1,5 @@
 /* Copyright (c) 2000, 2013, Oracle and/or its affiliates. All rights reserved.
-   Copyright (c) 2008, 2020, MariaDB Corporation.
+   Copyright (c) 2008, 2022, MariaDB Corporation.
 
    This program is free software; you can redistribute it and/or modify
    it under the terms of the GNU General Public License as published by
@@ -350,11 +350,14 @@ MY_STAT *my_stat(const char *path, MY_STAT *stat_area, myf my_flags)
                                            my_flags)))
       goto error;
 #ifndef _WIN32
-    if (! stat((char *) path, (struct stat *) stat_area) )
-      DBUG_RETURN(stat_area);
+  if (!stat((char *) path, (struct stat *) stat_area))
+  {
+    MSAN_STAT_WORKAROUND(stat_area);
+    DBUG_RETURN(stat_area);
+  }
 #else
-    if (! my_win_stat(path, stat_area) )
-      DBUG_RETURN(stat_area);
+  if (!my_win_stat(path, stat_area))
+    DBUG_RETURN(stat_area);
 #endif
   DBUG_PRINT("error",("Got errno: %d from stat", errno));
   my_errno= errno;
diff --git a/mysys/my_symlink.c b/mysys/my_symlink.c
index 323ae69a39c..8238e501e7f 100644
--- a/mysys/my_symlink.c
+++ b/mysys/my_symlink.c
@@ -1,6 +1,6 @@
 /*
    Copyright (c) 2001, 2011, Oracle and/or its affiliates
-   Copyright (c) 2010, 2017, MariaDB
+   Copyright (c) 2010, 2022, MariaDB
 
    This program is free software; you can redistribute it and/or modify
    it under the terms of the GNU General Public License as published by
@@ -113,7 +113,10 @@ int my_is_symlink(const char *filename __attribute__((unused)))
 {
 #if defined (HAVE_LSTAT) && defined (S_ISLNK)
   struct stat stat_buff;
-  return !lstat(filename, &stat_buff) && S_ISLNK(stat_buff.st_mode);
+  if (lstat(filename, &stat_buff))
+    return 0;
+  MSAN_STAT_WORKAROUND(&stat_buff);
+  return !!S_ISLNK(stat_buff.st_mode);
 #elif defined (_WIN32)
   DWORD dwAttr = GetFileAttributes(filename);
   return (dwAttr != INVALID_FILE_ATTRIBUTES) &&
diff --git a/sql/datadict.cc b/sql/datadict.cc
index e09eee98565..37f90d0309a 100644
--- a/sql/datadict.cc
+++ b/sql/datadict.cc
@@ -128,6 +128,8 @@ Table_type dd_frm_type(THD *thd, char *path, LEX_CSTRING *engine_name)
     if (mysql_file_fstat(file, &state, MYF(MY_WME)))
       goto err;
 
+    MSAN_STAT_WORKAROUND(&state);
+
     if (mysql_file_seek(file, 0, SEEK_SET, MYF(MY_WME)))
       goto err;
 
diff --git a/sql/discover.cc b/sql/discover.cc
index 4267f97cf59..22d7008630a 100644
--- a/sql/discover.cc
+++ b/sql/discover.cc
@@ -1,5 +1,5 @@
 /* Copyright (c) 2004, 2010, Oracle and/or its affiliates. All rights reserved.
-   Copyright (c) 2009, 2020, MariaDB Corporation.
+   Copyright (c) 2009, 2022, MariaDB Corporation.
 
    This program is free software; you can redistribute it and/or modify
    it under the terms of the GNU General Public License as published by
@@ -72,6 +72,7 @@ int readfrm(const char *name, const uchar **frmdata, size_t *len)
   error= 2;
   if (mysql_file_fstat(file, &state, MYF(0)))
     goto err;
+  MSAN_STAT_WORKAROUND(&state);
   read_len= (size_t)MY_MIN(FRM_MAX_SIZE, state.st_size); // safety
 
   // Read whole frm file
diff --git a/sql/parse_file.cc b/sql/parse_file.cc
index 59b4027a352..78093316d88 100644
--- a/sql/parse_file.cc
+++ b/sql/parse_file.cc
@@ -415,6 +415,8 @@ sql_parse_prepare(const LEX_CSTRING *file_name, MEM_ROOT *mem_root,
     DBUG_RETURN(0);
   }
 
+  MSAN_STAT_WORKAROUND(&stat_info);
+
   if (stat_info.st_size > INT_MAX-1)
   {
     my_error(ER_FPARSER_TOO_BIG_FILE, MYF(0), file_name->str);
diff --git a/storage/innobase/os/os0file.cc b/storage/innobase/os/os0file.cc
index eb9b4e00bd2..fb240943298 100644
--- a/storage/innobase/os/os0file.cc
+++ b/storage/innobase/os/os0file.cc
@@ -953,7 +953,7 @@ os_file_status_posix(
 
 	if (!ret) {
 		/* file exists, everything OK */
-
+		MSAN_STAT_WORKAROUND(&statinfo);
 	} else if (errno == ENOENT || errno == ENOTDIR || errno == ENAMETOOLONG) {
 		/* file does not exist */
 		return(true);
@@ -1548,8 +1548,10 @@ bool os_file_close_func(os_file_t file)
 os_offset_t
 os_file_get_size(os_file_t file)
 {
-	struct stat statbuf;
-	return fstat(file, &statbuf) ? os_offset_t(-1) : statbuf.st_size;
+  struct stat statbuf;
+  if (fstat(file, &statbuf)) return os_offset_t(-1);
+  MSAN_STAT_WORKAROUND(&statbuf);
+  return statbuf.st_size;
 }
 
 /** Gets a file size.
@@ -1566,6 +1568,7 @@ os_file_get_size(
 	int	ret = stat(filename, &s);
 
 	if (ret == 0) {
+		MSAN_STAT_WORKAROUND(&s);
 		file_size.m_total_size = s.st_size;
 		/* st_blocks is in 512 byte sized blocks */
 		file_size.m_alloc_size = s.st_blocks * 512;
@@ -1610,6 +1613,8 @@ os_file_get_status_posix(
 		return(DB_FAIL);
 	}
 
+	MSAN_STAT_WORKAROUND(statinfo);
+
 	switch (statinfo->st_mode & S_IFMT) {
 	case S_IFDIR:
 		stat_info->type = OS_FILE_TYPE_DIR;
@@ -3300,6 +3305,7 @@ fallback:
 		if (fstat(file, &statbuf)) {
 			err = errno;
 		} else {
+			MSAN_STAT_WORKAROUND(&statbuf);
 			os_offset_t current_size = statbuf.st_size;
 			if (current_size >= size) {
 				return true;
@@ -4186,6 +4192,7 @@ void fil_node_t::find_metadata(os_file_t file
 #else
 	struct stat sbuf;
 	if (!statbuf && !fstat(file, &sbuf)) {
+		MSAN_STAT_WORKAROUND(&sbuf);
 		statbuf = &sbuf;
 	}
 	if (statbuf) {
@@ -4229,6 +4236,7 @@ bool fil_node_t::read_page0()
 	if (fstat(handle, &statbuf)) {
 		return false;
 	}
+	MSAN_STAT_WORKAROUND(&statbuf);
 	os_offset_t size_bytes = statbuf.st_size;
 #else
 	os_offset_t size_bytes = os_file_get_size(handle);
diff --git a/strings/my_vsnprintf.c b/strings/my_vsnprintf.c
index a2e3f9b738d..8b4dc5da561 100644
--- a/strings/my_vsnprintf.c
+++ b/strings/my_vsnprintf.c
@@ -704,10 +704,11 @@ size_t my_vsnprintf_ex(CHARSET_INFO *cs, char *to, size_t n,
     }
     else if (*fmt == 'f' || *fmt == 'g')
     {
+      double d;
 #if __has_feature(memory_sanitizer)         /* QQ: MSAN has double trouble? */
       __msan_check_mem_is_initialized(ap, sizeof(double));
 #endif
-      double d= va_arg(ap, double);
+      d= va_arg(ap, double);
 #if __has_feature(memory_sanitizer)        /* QQ: MSAN has double trouble? */
       __msan_unpoison(&d, sizeof(double));
 #endif