diff --git a/mysql-test/suite/galera/r/galera_skip_fk_check_ist.result b/mysql-test/suite/galera/r/galera_skip_fk_check_ist.result
new file mode 100644
index 00000000000..b6de6f44c87
--- /dev/null
+++ b/mysql-test/suite/galera/r/galera_skip_fk_check_ist.result
@@ -0,0 +1,102 @@
+connection node_4;
+connection node_3;
+connection node_2;
+connection node_1;
+connection node_1;
+connection node_2;
+connection node_3;
+connection node_4;
+connection node_1;
+CREATE TABLE parent (
+id INT PRIMARY KEY
+) ENGINE=InnoDB;
+CREATE TABLE child (
+id INT PRIMARY KEY,
+parent_id INT,
+KEY (parent_id),
+CONSTRAINT FOREIGN KEY (parent_id) REFERENCES parent(id)
+) ENGINE=InnoDB;
+INSERT INTO parent VALUES (1), (2);
+connection node_4;
+SET SESSION wsrep_on = OFF;
+DELETE FROM parent;
+SET SESSION wsrep_on = ON;
+Shutting down server 4
+connection node_1;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+connection node_2;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+connection node_3;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+Server 4 left the cluster
+connection node_1;
+INSERT INTO child VALUES (1, 1);
+connection node_4;
+Restarting server 4 with disabled FK checks during IST
+include/assert_grep.inc [no FK constraint failure]
+Server 4
+SELECT COUNT(*) AS EXPECT_0 FROM parent;
+EXPECT_0
+0
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+EXPECT_1
+1
+connection node_1;
+Server 1
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+EXPECT_2
+2
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+EXPECT_1
+1
+connection node_2;
+Server 2
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+EXPECT_2
+2
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+EXPECT_1
+1
+connection node_3;
+Server 3
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+EXPECT_2
+2
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+EXPECT_1
+1
+Causing server 4 inconsistency with failed FK check on apply
+INSERT INTO child VALUES (2, 2);
+connection node_1;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+connection node_2;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+connection node_3;
+SET SESSION wsrep_on = ON;
+SET SESSION wsrep_sync_wait = 15;
+Server 4 is non-primary
+connection node_4;
+SET SESSION wsrep_on = OFF;
+include/assert_grep.inc [FK constraint failure]
+Restarting server 4 with enabled FK checks during IST
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+EXPECT_2
+2
+SELECT COUNT(*) AS EXPECT_2 FROM child;
+EXPECT_2
+2
+CALL mtr.add_suppression("Slave SQL: Could not execute Write_rows_v1 event");
+CALL mtr.add_suppression("Event 3 Write_rows_v1 apply failed");
+CALL mtr.add_suppression("Inconsistency detected: Inconsistent by consensus");
+CALL mtr.add_suppression("Failed to apply write set");
+DROP TABLE child;
+DROP TABLE parent;
+disconnect node_4;
+disconnect node_3;
+disconnect node_2;
+disconnect node_1;
diff --git a/mysql-test/suite/galera/t/galera_skip_fk_check_ist.cnf b/mysql-test/suite/galera/t/galera_skip_fk_check_ist.cnf
new file mode 100644
index 00000000000..7909883b0ea
--- /dev/null
+++ b/mysql-test/suite/galera/t/galera_skip_fk_check_ist.cnf
@@ -0,0 +1,16 @@
+!include ../galera_4nodes.cnf
+
+[mysqld.1]
+wsrep_node_name='node_1'
+
+[mysqld.2]
+wsrep_node_name='node_2'
+
+[mysqld.3]
+wsrep_node_name='node_3'
+
+[mysqld.4]
+wsrep_node_name='node_4'
+
+[ENV]
+galera_cluster_size=4
diff --git a/mysql-test/suite/galera/t/galera_skip_fk_check_ist.test b/mysql-test/suite/galera/t/galera_skip_fk_check_ist.test
new file mode 100644
index 00000000000..338d95c5cda
--- /dev/null
+++ b/mysql-test/suite/galera/t/galera_skip_fk_check_ist.test
@@ -0,0 +1,136 @@
+#
+# MDEV-34822: Skip FK checks in Galera during applying in IST.
+#
+
+--source include/have_innodb.inc
+--source include/galera_cluster.inc
+--source include/big_test.inc
+
+# Save original auto_increment_offset values.
+--let $node_1=node_1
+--let $node_2=node_2
+--let $node_3=node_3
+--let $node_4=node_4
+--source include/auto_increment_offset_save.inc
+
+# Create parent and child tables.
+--connection node_1
+CREATE TABLE parent (
+	id INT PRIMARY KEY
+) ENGINE=InnoDB;
+
+CREATE TABLE child (
+	id INT PRIMARY KEY,
+	parent_id INT,
+	KEY (parent_id),
+	CONSTRAINT FOREIGN KEY (parent_id) REFERENCES parent(id)
+) ENGINE=InnoDB;
+
+# Fill the parent table with rows that will later be used by the child.
+INSERT INTO parent VALUES (1), (2);
+
+# Wait until the row is replicated on node #4.
+--connection node_4
+--let $wait_condition = SELECT COUNT(*) = 2 FROM parent
+--source include/wait_condition.inc
+
+# Clear the parent table on node #4 and leave the cluster.
+SET SESSION wsrep_on = OFF;
+DELETE FROM parent;
+SET SESSION wsrep_on = ON;
+--echo Shutting down server 4
+--source include/shutdown_mysqld.inc
+
+# Wait for node #4 to leave the cluster.
+--let $members = 3
+--connection node_1
+--source include/wsrep_wait_membership.inc
+--connection node_2
+--source include/wsrep_wait_membership.inc
+--connection node_3
+--source include/wsrep_wait_membership.inc
+--echo Server 4 left the cluster
+
+# Insert a child row that will be sent to node #4 with IST.
+--connection node_1
+INSERT INTO child VALUES (1, 1);
+
+--connection node_4
+--echo Restarting server 4 with disabled FK checks during IST
+--let $start_mysqld_params = --wsrep_mode=APPLIER_SKIP_FK_CHECKS_IN_IST
+--source include/start_mysqld.inc
+
+--let $assert_select = foreign key constraint fails
+--let $assert_count = 0
+--let $assert_text = no FK constraint failure
+--let $assert_only_after = CURRENT_TEST
+--let $assert_file = $MYSQLTEST_VARDIR/log/mysqld.4.err
+--source include/assert_grep.inc
+
+# Child row insert is applied even though there's no parent row.
+--echo Server 4
+SELECT COUNT(*) AS EXPECT_0 FROM parent;
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+
+# Check other nodes have both parent and child rows.
+--connection node_1
+--echo Server 1
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+
+--connection node_2
+--echo Server 2
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+
+--connection node_3
+--echo Server 3
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+SELECT COUNT(*) AS EXPECT_1 FROM child;
+
+# Test part below ensures that regular apply still fails on FK check.
+
+--echo Causing server 4 inconsistency with failed FK check on apply
+INSERT INTO child VALUES (2, 2);
+
+# Wait for node #4 to become inconsistent and leave the primary component.
+--let $members = 3
+--connection node_1
+--source include/wsrep_wait_membership.inc
+--connection node_2
+--source include/wsrep_wait_membership.inc
+--connection node_3
+--source include/wsrep_wait_membership.inc
+--echo Server 4 is non-primary
+
+--connection node_4
+SET SESSION wsrep_on = OFF;
+--let $assert_select = foreign key constraint fails
+# Exact count may depend on the log level.
+--let $assert_count =
+--let $assert_match = foreign key constraint fails
+--let $assert_text = FK constraint failure
+--let $assert_only_after = CURRENT_TEST
+--let $assert_file = $MYSQLTEST_VARDIR/log/mysqld.4.err
+--source include/assert_grep.inc
+
+--echo Restarting server 4 with enabled FK checks during IST
+--let $start_mysqld_params =
+--source include/restart_mysqld.inc
+
+# Now everything is in sync.
+SELECT COUNT(*) AS EXPECT_2 FROM parent;
+SELECT COUNT(*) AS EXPECT_2 FROM child;
+
+CALL mtr.add_suppression("Slave SQL: Could not execute Write_rows_v1 event");
+CALL mtr.add_suppression("Event 3 Write_rows_v1 apply failed");
+CALL mtr.add_suppression("Inconsistency detected: Inconsistent by consensus");
+CALL mtr.add_suppression("Failed to apply write set");
+
+DROP TABLE child;
+DROP TABLE parent;
+
+# Restore original auto_increment_offset values.
+--source include/auto_increment_offset_restore.inc
+
+--source include/galera_end.inc
diff --git a/mysql-test/suite/sys_vars/r/sysvars_wsrep.result b/mysql-test/suite/sys_vars/r/sysvars_wsrep.result
index 9310119071c..92b147a76ba 100644
--- a/mysql-test/suite/sys_vars/r/sysvars_wsrep.result
+++ b/mysql-test/suite/sys_vars/r/sysvars_wsrep.result
@@ -327,7 +327,7 @@ VARIABLE_COMMENT	Set of WSREP features that are enabled
 NUMERIC_MIN_VALUE	NULL
 NUMERIC_MAX_VALUE	NULL
 NUMERIC_BLOCK_SIZE	NULL
-ENUM_VALUE_LIST	STRICT_REPLICATION,BINLOG_ROW_FORMAT_ONLY,REQUIRED_PRIMARY_KEY,REPLICATE_MYISAM,REPLICATE_ARIA,DISALLOW_LOCAL_GTID,BF_ABORT_MARIABACKUP
+ENUM_VALUE_LIST	STRICT_REPLICATION,BINLOG_ROW_FORMAT_ONLY,REQUIRED_PRIMARY_KEY,REPLICATE_MYISAM,REPLICATE_ARIA,DISALLOW_LOCAL_GTID,BF_ABORT_MARIABACKUP,APPLIER_SKIP_FK_CHECKS_IN_IST
 READ_ONLY	NO
 COMMAND_LINE_ARGUMENT	REQUIRED
 GLOBAL_VALUE_PATH	NULL
diff --git a/sql/sys_vars.cc b/sql/sys_vars.cc
index 29d20ec17e8..7d36820e6b4 100644
--- a/sql/sys_vars.cc
+++ b/sql/sys_vars.cc
@@ -6518,6 +6518,7 @@ static const char *wsrep_mode_names[]=
   "REPLICATE_ARIA",
   "DISALLOW_LOCAL_GTID",
   "BF_ABORT_MARIABACKUP",
+  "APPLIER_SKIP_FK_CHECKS_IN_IST",
   NullS
 };
 static Sys_var_set Sys_wsrep_mode(
diff --git a/sql/wsrep_high_priority_service.cc b/sql/wsrep_high_priority_service.cc
index af7c9f010bd..bb57aa59930 100644
--- a/sql/wsrep_high_priority_service.cc
+++ b/sql/wsrep_high_priority_service.cc
@@ -115,7 +115,9 @@ static void wsrep_setup_uk_and_fk_checks(THD* thd)
   else
     thd->variables.option_bits&= ~OPTION_RELAXED_UNIQUE_CHECKS;
 
-  if (wsrep_slave_FK_checks == FALSE)
+  if (wsrep_slave_FK_checks == FALSE ||
+      (wsrep_check_mode(WSREP_MODE_APPLIER_SKIP_FK_CHECKS_IN_IST) &&
+       !wsrep_ready_get()))
     thd->variables.option_bits|= OPTION_NO_FOREIGN_KEY_CHECKS;
   else
     thd->variables.option_bits&= ~OPTION_NO_FOREIGN_KEY_CHECKS;
diff --git a/sql/wsrep_mysqld.h b/sql/wsrep_mysqld.h
index 39c7a42d230..9be4769b5fc 100644
--- a/sql/wsrep_mysqld.h
+++ b/sql/wsrep_mysqld.h
@@ -131,7 +131,8 @@ enum enum_wsrep_mode {
   WSREP_MODE_REPLICATE_MYISAM= (1ULL << 3),
   WSREP_MODE_REPLICATE_ARIA= (1ULL << 4),
   WSREP_MODE_DISALLOW_LOCAL_GTID= (1ULL << 5),
-  WSREP_MODE_BF_MARIABACKUP= (1ULL << 6)
+  WSREP_MODE_BF_MARIABACKUP= (1ULL << 6),
+  WSREP_MODE_APPLIER_SKIP_FK_CHECKS_IN_IST= (1ULL << 7)
 };
 
 // Streaming Replication