diff --git a/mysql-test/suite/binlog/r/binlog_empty_xa_prepared.result b/mysql-test/suite/binlog/r/binlog_empty_xa_prepared.result
new file mode 100644
index 00000000000..eb96f7bb984
--- /dev/null
+++ b/mysql-test/suite/binlog/r/binlog_empty_xa_prepared.result
@@ -0,0 +1,31 @@
+CREATE TEMPORARY SEQUENCE seq_1;
+XA START '3';
+CREATE TEMPORARY TABLE tmp_1(c INT);
+XA END '3';
+XA PREPARE '3';
+DROP TEMPORARY TABLE tmp_1;
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+ALTER TABLE tmp_1 DROP COLUMN c;
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+DROP TEMPORARY SEQUENCE seq_1;
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+ALTER SEQUENCE seq_1 INCREMENT BY 1;
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+CREATE TEMPORARY TABLE tmp_2(c INT);
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+CREATE TEMPORARY SEQUENCE seq_2;
+ERROR XAE07: XAER_RMFAIL: The command cannot be executed when global transaction is in the  PREPARED state
+XA ROLLBACK '3';
+# Proof of  correct logging incl empty XA-PREPARE
+include/show_binlog_events.inc
+Log_name	Pos	Event_type	Server_id	End_log_pos	Info
+master-bin.000001	#	Gtid	#	#	GTID #-#-#
+master-bin.000001	#	Query	#	#	use `test`; CREATE TEMPORARY SEQUENCE seq_1
+master-bin.000001	#	Gtid	#	#	BEGIN GTID #-#-#
+master-bin.000001	#	Query	#	#	use `test`; CREATE TEMPORARY TABLE tmp_1(c INT)
+master-bin.000001	#	Query	#	#	COMMIT
+master-bin.000001	#	Gtid	#	#	XA START X'33',X'',1 GTID #-#-#
+master-bin.000001	#	Query	#	#	XA END X'33',X'',1
+master-bin.000001	#	XA_prepare	#	#	XA PREPARE X'33',X'',1
+master-bin.000001	#	Gtid	#	#	GTID #-#-#
+master-bin.000001	#	Query	#	#	XA ROLLBACK X'33',X'',1
diff --git a/mysql-test/suite/binlog/t/binlog_empty_xa_prepared.test b/mysql-test/suite/binlog/t/binlog_empty_xa_prepared.test
new file mode 100644
index 00000000000..7f923f71f81
--- /dev/null
+++ b/mysql-test/suite/binlog/t/binlog_empty_xa_prepared.test
@@ -0,0 +1,35 @@
+# The test verifies execution and binary logging of user XA that produce empty
+# XA-PREPARE group of events.
+
+--source include/have_binlog_format_mixed.inc
+--source include/have_innodb.inc
+
+
+# MDEV-22420 DDL on temporary object is prohibited when XA is in prepare state
+
+# Temporary sequnce may not be created within a transaction
+CREATE TEMPORARY SEQUENCE seq_1;
+
+XA START '3';
+CREATE TEMPORARY TABLE tmp_1(c INT);
+XA END '3';
+XA PREPARE '3';
+--error ER_XAER_RMFAIL
+DROP TEMPORARY TABLE tmp_1;
+--error ER_XAER_RMFAIL
+ALTER TABLE tmp_1 DROP COLUMN c;
+--error ER_XAER_RMFAIL
+DROP TEMPORARY SEQUENCE seq_1;
+--error ER_XAER_RMFAIL
+ALTER SEQUENCE seq_1 INCREMENT BY 1;
+
+--error ER_XAER_RMFAIL
+CREATE TEMPORARY TABLE tmp_2(c INT);
+--error ER_XAER_RMFAIL
+CREATE TEMPORARY SEQUENCE seq_2;
+
+# Cleanup
+XA ROLLBACK '3';
+
+--echo # Proof of  correct logging incl empty XA-PREPARE
+--source include/show_binlog_events.inc
diff --git a/sql/sql_parse.cc b/sql/sql_parse.cc
index e35ee16cf4b..cd60472e81c 100644
--- a/sql/sql_parse.cc
+++ b/sql/sql_parse.cc
@@ -4890,6 +4890,8 @@ mysql_execute_command(THD *thd)
     }
     else
     {
+      if (thd->transaction->xid_state.check_has_uncommitted_xa())
+        goto error;
       status_var_decrement(thd->status_var.com_stat[lex->sql_command]);
       status_var_increment(thd->status_var.com_drop_tmp_table);